[İş Radarı](https://jobradar.live/) / [Jobs](https://jobradar.live/ilanlar) / Clinical Trial Manager/Senior Clinical Trial Manager Active On-site New York, NY Posted · 20.09.2026 Greenhouse (US) # Clinical Trial Manager/Senior Clinical Trial Manager Axsome Therapeutics Axsome Therapeutics is a biopharmaceutical company leading a new era in the treatment of central nervous system (CNS) conditions. We deliver scientific breakthroughs by identifying critical gaps in care and develop differentiated products with a focus on novel mechanisms of action that enable meaningful advancements in patient outcomes. Our industry-leading neuroscience portfolio includes FDA-approved treatments for major depressive disorder, agitation associated with dementia due to Alzheimer’s disease, excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea, and migraine, as well as multiple novel product candidates addressing a broad range of serious neurological and psychiatric conditions that impact over 150 million people in the United States. Together, we are on a mission to solve some of the brain’s biggest problems so patients and their loved ones can flourish. For more information, please visit us at www.axsome.com and follow us on LinkedIn and X. About This Role: Axsome Therapeutics is seeking a Clinical Trial Manager/Senior Clinical Trial Manager who will be the primary operational lead for a study and will lead the cross-functional team for execution of the study. The Clinical Trial Manager/Senior Clinical Trial Manager provides operational leadership to the study team to ensure project milestones deliver on time, within budget, high quality, and in compliance with the ICH / GCP, regulatory authority’s regulations/guidelines, and applicable SOPs. This position will manage essential duties and responsibilities as independently as possible, with guidance and oversight provided by the program director when needed.  This role is based at Axsome’s HQ in New York City with an on-site requirement of at least three days per week. We are unable to consider candidates who are looking for fully remote roles.    Job Responsibilities and Duties include, but are not limited to, the following: Responsible for leading all operational aspects and progress of clinical trial which can include but is not limited to: study planning activities; study execution including ongoing tracking of all applicable performance metrics; and quality indicators  Serve as an escalation point and resource for study team and investigative sites  Facilitate and review the site feasibility process and oversee the site selection processes  Oversee subject recruitment / retention strategy and related initiatives  Provide operational input for study documents such as synopsis, and protocol, and develops/approves ICFs, CRFs, CRF Completion Guidelines, study plans, including Clinical Monitoring Plan, Protocol Deviation Plan, Risk Management Plan, etc.  Develop protocol training materials for CRAs and site-facing materials for SEVs, SIVs and ad-hoc training  Responsible for oversight of study teams in review of clinical data in conjunction with Data Management; provides guidance on issues / queries as needed and implements risk management concepts as appropriate  In conjunction with the Lead CRA, this position will be responsible for motivating and leading the assigned clinical monitoring team to deliver on study timelines and milestone deliverables  Oversee monitoring visit schedule to ensure compliance with frequency set forth in CMP  Review site monitoring visit reports for clarity and completeness and escalates issues identified   Participate in clinical vendor selection process as a part of outsourcing activities  Assist in the review and approval of vendor and site budgets along with the study director  Provide oversight for all clinical vendor activities (e.g.,, specifications development, UATs, issues escalations, KPIs)  Work closely with QA to drive CAPA review, implementation, and completion  Oversee the eTMF set-up, ongoing quality review, and final reconciliation of study documents   Ensure that all aspects of GCP compliance and audit/inspection readiness are maintained throughout trial conduct  Create, manage, measure, and report timelines for milestone deliverables  Proactively manage and identify potential study issues and risks as well as recommend and implement solutions with key internal / external stakeholders  Lead internal team meetings, and other trial-specific meetings  Participate in the development, review, and implementation of departmental SOPs, initiatives, and processes  May conduct Site Evaluation visits (SEVs) and Site Initiation Visits (SIVs)  Review and approve vendor invoices for all clinical trial vendors including investigative sites  Requirements / Qualifications Bachelor’s degree required; preference to candidates with a scientific background   At least 5 years clinical research experience in a biotech/pharmaceutical company or clinical research organization (CRO) for Clinical Trial Manager level  At least 7 years clinical research experience in a biotech/pharmaceutical company or clinical research organization (CRO) for Senior Clinical Trial Manager level  Preference to candidates with prior small company experience and 1+ years management experience  Ability to work on site Monday, Tuesday & Thursday. We are unable to consider candidates who are looking for fully remote roles  Experience and Knowledge: Knowledgeable of clinical research operations, including interpretation and implementation of FDA regulations / ICH / GCP guidelines, is required  Ability to work on complex or multiple projects and exercise independent judgment within generally defined practices and policies that lead to obtaining results  Strong attention to detail, time management and excellent organizational skills  Strong interpersonal skills and communication skills (both written and oral)  Ability to problem solve, delegate appropriate tasks, work within a team environment and mentor junior team members such as CTAs/CRAs.   Excellent sense of urgency to deliver at/surpass study conduct targets  Strong leadership skills, self-motivated, adaptable to a dynamic environment  Comfortable multi-tasking in a fast-paced small company environment and able to adjust workload based upon changing priorities  Preference to energetic candidates with a desire to think “outside the box”  Willingness to travel as needed, up to 20%   Salary and Benefits: The anticipated salary range for this role is $130,000 - $150,000. Axsome offers a competitive employment package that includes an annual bonus, significant equity and a generous benefits package. Axsome is committed to equal employment opportunity and providing reasonable accommodations to applicants with physical and/or mental disabilities. We value and encourage diversity and solicit applications from all qualified applicants without regard to race, color, gender, sex, age, religion, creed, national origin, sexual orientation, gender identity, ancestry, citizenship, marital status, physical or mental disability, medical condition, veteran status, genetic information, or any other characteristic protected by federal, state, or local law.  Axsome Therapeutics does not accept unsolicited resumes from recruiters or third-party recruitment agencies and will not pay placement fees for unsolicited candidates that are sent to hiring managers, the HR team or other Axsome team members. Only approved vendors who have been explicitly asked to support a specific search will receive access to our Applicant Tracking System to submit candidates for consideration. This job was verified from Greenhouse (US). Applications are completed on the original source. [Apply on the original listing ↗](https://jobradar.live/ilan/ab20a247-b31a-4c06-bbbe-59653910d2a8/git) ## Stop searching one by one for roles like this. Upload your resume or enter your target roles to see your first 3 matches for free. [Find jobs for me →](https://jobradar.live/uye/kayit) Your resume is never shared with employers; it is processed only for matching. Something wrong with this job?