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Bothell, Washington, United States
Posted · 20.09.2026
Greenhouse (US)

# Senior Manager, Global Value and Access

Immunome, Inc.

Company Overview Immunome is a clinical-stage targeted oncology company committed to developing first-in-class and best-in-class targeted cancer therapies. We are advancing an innovative portfolio of therapeutics, supported by a leadership team with deep experience in the design, development, and commercialization of cutting-edge therapies, including antibody-drug conjugates. Our pipeline includes varegacestat, an investigational gamma secretase inhibitor for which an NDA has been accepted by the U.S. FDA; IM-1021, a clinical-stage ROR1 ADC; IM-1617, a clinical-stage solid tumor ADC; and IM-3050, a clinical-stage FAP-targeted radioligand therapy. We are also advancing a broad portfolio of early-stage ADCs pursuing undisclosed solid tumor targets. Position Overview Immunome is seeking a Senior&nbsp;Manager,&nbsp;Global Value and Access to support global&nbsp;health&nbsp;economics and outcomes research (HEOR) and market access activities in the US and ex-US for our oncology portfolio. This role will primarily lead the execution of HEOR studies and evidence-generation deliverables, while flexing into broader market access priorities as Immunome prepares for a potential launch of its lead asset, varegacestat.&nbsp;&nbsp; The successful candidate will combine strong HEOR technical and project management capabilities with a practical understanding of US and ex-US payer evidence needs, value communication including field tools, and new drug launch. This is a highly visible opportunity for an individual who thrives in a fast-paced environment, learns quickly, and is eager to take on new responsibilities. The level will be&nbsp;commensurate&nbsp;with experience; the ideal candidate will bring enough launch exposure to add value&nbsp;immediately&nbsp;while continuing to grow across Global Value and Access.&nbsp; Responsibilities HEOR Strategy and Evidence Planning&nbsp;&nbsp; Support integrated HEOR and real-world evidence strategies aligned with clinical development, medical, regulatory, and market access priorities.&nbsp; Identify&nbsp;evidence gaps and translate payer, health technology assessment (HTA), and business questions into fit-for-purpose research plans and analyses.&nbsp; Provide HEOR input to evidence-generation plans, value propositions, and launch- deliverables for the lead asset and broader portfolio. &nbsp; HEOR Study Execution&nbsp;&nbsp; Lead real-world evidence studies, including burden of illness, treatment patterns, healthcare resource use, real-world comparative effectiveness, and epidemiology studies using claims, electronic health records, and other secondary data sources.&nbsp; Develop cost-effectiveness and budget-impact models, from early economic models that inform development and pricing strategy to submission-ready models adapted for HTA bodies ex-US. &nbsp; Conduct systematic literature reviews, indirect treatment comparisons and network meta-analyses.&nbsp; Develop and review study protocols, analysis plans, reports, abstracts, posters, and manuscripts; ensure scientific rigor, timely&nbsp;delivery, and clear communication of decision-relevant findings.&nbsp;&nbsp; Launch Readiness and Market Access Support&nbsp;&nbsp; Own the launch deliverables including AMCP dossier, global value dossier, budget-impact model, and cost-effectiveness models.&nbsp; Flex into launch market access workstreams, contributing to payer value propositions,&nbsp;payer research, objection handling, and access field tools.&nbsp; Translate clinical and economic evidence into clear payer narratives and materials that support reimbursement and patient access. &nbsp; Monitor payer, HTA, reimbursement, policy, and competitive trends and assess implications for evidence strategy and launch execution. &nbsp; Vendor and Project Management&nbsp;&nbsp; Manage HEOR consultants, data partners, and agencies, including scope, deliverables, timelines, budgets, and quality.&nbsp; Own multiple concurrent projects, proactively resolving risks and adapting priorities in a rapidly changing environment. &nbsp; Ensure work meets internal standards and applicable scientific, legal, regulatory, and publication requirements. &nbsp; Cross-Functional Collaboration and Communication&nbsp;&nbsp; Serve as a Global Value and Access partner on asset and launch teams, collaborating with Clinical Development, Medical Affairs, Regulatory, Commercial, Finance, and other functions.&nbsp; Influence without direct authority, communicate complex concepts clearly, and flex beyond core responsibilities with curiosity, urgency, sound judgment, and a team-first mindset. &nbsp; Qualifications Advanced degree (Ph.D., Pharm.D., M.S., M.P.H., or equivalent) in health economics, outcomes research, epidemiology, public health, pharmacy, health services research, or a related discipline preferred; a bachelor's degree with directly relevant experience will be considered.&nbsp; Minimum of 3 years of work experience in HEOR, real-world evidence, market access, or a related&nbsp;function within biotechnology, pharmaceuticals, managed care, or consulting.&nbsp; Demonstrated experience executing HEOR or real-world evidence studies from concept through final deliverable. &nbsp; Track record of peer-reviewed publications and scientific presentations at HEOR or clinical congresses. Experience translating clinical, economic, and outcomes&nbsp;evidence into payer value messages or market access deliverables.&nbsp; Launch experience preferred&nbsp;but not&nbsp;required.&nbsp; Oncology, rare disease, or specialty product experience preferred. &nbsp; Experience managing external research partners, consultants, data vendors, or agencies. &nbsp; Knowledge and Skills Strong project management skills and ability to independently drive multiple&nbsp;high-priority&nbsp;workstreams against tight timelines.&nbsp; Ability to critically evaluate study designs and analyses and communicate actionable conclusions. &nbsp; Sound understanding of U.S. and global payer, reimbursement, HTA, and evidence requirements. &nbsp; Excellent written and verbal communication skills, including scientific writing and presentation capabilities. &nbsp; High learning agility, intellectual curiosity, passion, and drive to take on new challenges and grow quickly. &nbsp; Hands-on, resourceful, and comfortable operating with ambiguity in a fast-paced, dynamic biotechnology environment. &nbsp; Collaborative working style with a willingness to flex across HEOR and market access priorities. &nbsp; Exceptional organizational, analytical, problem-solving, and judgment skills, with close attention to detail.&nbsp; Washington State Pay Range$179,611&mdash;$211,641 USDE/E/O Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. E-Verify Immunome, Inc. is a participant in E-Verify. Please review the following notices: E-Verify Participation Poster | Right to Work Poster (English) | Right to Work Poster (Spanish).

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